Pharmaceutical Gelatin: Icyo aricyo n'impamvu bifite akamaro

Gelatin, kimwe mu bikoresho bikoreshwa cyane, bifite akamaro kanini mu gukora imiti kubera ko ikoreshwa cyane mu bihingwa by’imiti ibihumbi. Imiti ya gelatine ikomoka kuri bovine (inyama zinka) cyangwa izindi nkomoko, ikoreshwa nkimodoka yibiyobyabwenge nibikoresho byubuvuzi.

Muri iki kiganiro cyose, umusomyi azasesengura incamake, inyungu, nimpamvu zituma gelatine yimiti ningirakamaro nimpamvu igomba kugurwa kubitanga byinshi: gelatine yimiti ni biopolymer isanzwe ikomoka kuri kolagen ifite ingaruka zikomeye mubuzima. Gelatin capsulesno kurekura impapuro zabonetse na hydrolysis igice cyakozwe mubikoresho fatizo nka kolagen (inyama y'inka) cyangwa amafi.

Niki?

Ibikoresho biri muri kolagen, nk'amagufwa yinyamaswa, impu, nimpu, bitetse kugirango bitange gelatine; ingurube n'inka ni isoko izwi. Iyi poroteyine idasanzwe irashobora gukoreshwa mubice kuva ibiryo kugeza mu nganda, harimo kwisiga no gufotora.

Uruganda rwa farumasi rukoresha gelatine kugirango rutange capsules na capsules yoroshye. Usibye capsules, inganda zikora kandi ibinini, emulisitiya, suppositions, na sirupe. Gelatin yemerewe kuba ibiribwa (imaze imyaka irenga 125 ikoreshwa ninganda zibiribwa!) Kandi yemerewe na FDA nkumutekano, ishyigikira imikoreshereze yayo ihoraho kandi iherezo ryumutekano.

Imiti ya gelatine:Niki?

Yari imiti ya gelatineikubiyemo ibicuruzwa byakozwe gusa kugirango bikoreshwe mu buvuzi no mu bucuruzi bw'ubuzima. Iyi gelatine, ubusanzwe ikomoka ku nyamaswa zo mu bwoko bwa kolagen zikomoka ku ngingo zihuza, cyane cyane ziva mu nka cyangwa ingurube, zigengwa n’umutekano muke cyane n’ubuziranenge.

Inkomoko na Kamere yibicuruzwa Byakoreshejwe muri Imiti ya gelatine 

Gelatin ikomoka ku magufa y’inyamabere no mu bwihisho kandi irashobora guhinduka muburyo bwo gushonga binyuze muri aside (Ubwoko A) cyangwa alkaline (Ubwoko B). Gelatin iva mu nyama zinka zirasanzwe kandi irashobora kwemezwa ko ari halal, ikirinda ibibazo byabayisilamu nibindi bibuza imirire.

Inyama y'inka: Isoko rusange

Gelatin iva mu nyama z'inkamolasses ikundwa mubikorwa byinshi bya farumasi, cyane cyane aho porotine gelatine idakwiye kubera imirire cyangwa umuco mubi. Bitume umuryango w’abayisilamu ufite ibyemezo bya halale, kubahiriza amategeko y’imirire ya kisilamu, hamwe n’ubwishingizi bw’ibicuruzwa bigaragara ko bifite umutekano kandi bikwiye.

Ibikurubikuru bya Imiti ya gelatine

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Ibyiciro by'ingenzi birimo:

Mbere yo kuvurwa:Ibikoresho fatizo (uruhu rwinka cyangwa uruhu rwingurube) rwogejwe kugirango rukureho indi myanda yose hamwe namavuta adakenewe kugirango ubuziranenge bwa gelatine.

Umuti wibanze:

Binyuramo inzira aho uvura ibikoresho bisukuye ukoresheje aside cyangwa umuti wa alkaline kugirango ugabanye kolagene mubice bito hamwe na acide amine yihariye; ibi bifasha guhinduka muri gelatine.

Gukuramo:

Kolagen yongeye kwezwa nuburyo bwinshi: kuyungurura, centrifugation, nibindi.

Kuma:

Nkigisubizo cyo kwezwa, igisubizo cyumishijwe kugirango ubone ibicuruzwa, biboneka mubucuruzi (muburyo bwifu nurupapuro) muruganda rwa farumasi.

Kuki ukoresha Gelatin muri farumasi?

Gelatin itanga imikorere yingirakamaro; birahumuriza kandi byizewe mubuvuzi. Gelatin ihindura imiti yifu cyangwa yamazi muri capsules yamizwe byoroshye, bigira ingaruka zikomeye kubarwayi no gutsinda neza. Imwe muma porogaramu isanzwe ni gelatin capsulesgushoboza gutanga imiti no kuyakira

Ikoreshwa rya gelatine muri farumasi

Gelatin ikoreshwa cyane muburyo bwa farumasi yimiti kuva ishobora gukora geles ya termogenique. Igiciro gito na antigenicite ituma iba umukandida mwiza mubikorwa byo gukora kandi byoroshye gelatin capsulesikoreshwa cyane cyane mu gutanga ibiyobyabwenge.

Gelatin Capsules : Kuringaniza Ingaruka hamwe Nibyoroshye

Gelatin ni kimwe mu bintu bikoreshwa mu bya farumasi mu gukora capsule. Ibi gelatin capsuleskora nkigishishwa cyoroshye gitwara ibiyobyabwenge mukigero cyihariye kandi gito, gushonga byoroshye mugifu no kurekura imiti nta buryohe cyangwa umunuko ushobora gutuma abantu badashaka kubimira.

Inyungu za gelatin capsules

Gelatin muri capsulesifite ibyiza bimwe, cyane cyane bijyanye na capsules hamwe na gelatine.

Korohereza igogorwa:

Gelatin nayo ntabwo ikora biofilm mumubiri, bityo imiti irekurwa vuba kandi neza.

Ibyiyumvo_Ibikoresho_Gukingira:

Gelatin irinda imiti okisijeni n'umucyo, bigatuma ihagarara neza muri farumasi igihe kirekire.

Guhindagurika:

Kuberako gelatin capsulesgushonga ku muvuduko utandukanye, zikoreshwa mugihe cyo kurekura igihe cyibikoresho bikora.

Microencapsulation na Hanze yayo

Hamwe na gelatin muri capsules, gelatine ikoreshwa muri microencapsulation - gutwikira uduce duto twibiyobyabwenge muri firime yoroheje yibintu bya gelatine. Kugenzura-kurekura ibiyobyabwenge nibiyobyabwenge bifite igipimo cyihariye, ahantu, cyangwa ibihe byo kurekura, bityo, ubu buhanga bugira uruhare runini muri byo.

Akamaro ka Imiti ya farumasi Gelatin 

Imiti ya farumasi gelatine nikintu kinini gifite isuku ikoreshwa nkigice cyingenzi cyemeza ko imiti na vitamine byakozwe neza, neza kandi neza

Uruhare rwa Imiti ya farumasi Gelatin mu Gutanga Ibiyobyabwenge

Gelatine yo mu rwego rwohejuru ikundwa mugihe cyo gufata ibiyobyabwenge kuko itanga imbaraga za gel. Iyi miterere idasanzwe hamwe na aside amine igizwe na glycine, proline, na alanine yemerera ibi bikoresho gushyirwaho geles zihamye zikoreshwa mugusohora kuramba kwa farumasi.

Porogaramu Zigezweho no guhanga udushya

Ubushakashatsi ntibuvumbura ubushobozi bwa gelatine burenze capsules zisanzwe. Mu guhanga udushya harimo hydrogels ishingiye kuri gelatine yo kumara igihe kirekire irekura ibiyobyabwenge na nanoparticles ya gelatine nk'abashoferi ba tekinoroji yo gutanga imiti igamije kuvura kanseri, ikagaragaza imikorere yayo n'akamaro kayo mu guteza imbere ibikoresho bishya by’ubuvuzi bugezweho.

Amahame yo hejuru yubuzima

Imiti yo mu rwego rwa farumasi yujuje ubuziranenge bwa farumasi yisi yose, nkibisangwa muri USP (Pharmacopeia yo muri Amerika) na EP (Pharmacopeia yu Burayi). Bisobanura ko gelatine ikoreshwa mubuvuzi itanduye kandi ifite ireme.

Akamaro k'ubuziranenge no gushakisha

Kubera iyo mpamvu, isoko rikomeye rya gelatine yo mu rwego rwa farumasi yo mu rwego rwo hejuru ryagaragaye ku isoko, bituma abakora inganda benshi babigiramo uruhare gelatingutanga kugirango byuzuze amahame akomeye. Inzego zita ku buzima ku isi zishishikajwe no gukora ibicuruzwa gelatin iva mu nyama z'inka n'inkomoko ya bovine kugirango itange ibicuruzwa bihoraho.

Umutekano no kugenzura ubuziranenge

Kugirango ukomeze kugirira icyizere ubwiza bwibicuruzwa bikoreshwa mu bya farumasi, abakora gelatine bakeneye kumenya neza ko ibyo batanga atari byiza gusa ahubwo bifite amateka yumutekano ahoraho. Ibi bikubiyemo kugenzura kenshi iminyururu itangwa, kwizerwa gukomeye no kubahiriza imikorere myiza yo gukora (GMP).

Gelatin nyinshi: Kwemeza amasoko nubuziranenge

Uruhare rwabacuruzi

Kubakora, kugura imiti ya gelatine cyangwa, byiza kurushaho, gelatinni ubwumvikane hagati yigiciro nubuziranenge. Abacuruzi bawe benshi (bagurisha gelatine kubwinshi) bemeza ko gelatine nziza yo mu rwego rwo hejuru itangwa ku bwinshi ariko ku giciro cyo hasi, amaherezo ifasha abayikora gukora imiti yimiti yubukungu idatanze ubuziranenge.

Guhitamo neza

Iyo bigeze kuri gelatine, cyane cyane umwihariko gelatin bovine halal) ubwoko, guhitamo igikwiye gelatinutanga isoko ni ngombwa. Ababikora ntibagomba gushakisha abatanga ibicuruzwa gusa ntibatanga ibiciro byapiganwa gusa ahubwo nibisabwa murwego rwo hejuru kandi rwiza.

Kazoza ka Gelatin muri Farumasi

Kubera ubwo bwiyongere bwiyongera muri sisitemu yo gutanga imiti igezweho, imikoreshereze ya gelatine irashobora kwaguka. Nubwo, nubwo iterambere ryubumenyi bwa farumasi, kunoza imiterere ya gelatine no kuyikoresha bizakomeza kuba ingorabahizi. Ibi bizibanda cyane kubuvuzi bushingiye ku barwayi.

Kwakira udushya n'imigenzo

Nubwo ubushakashatsi bwibanze kuri physiochemiki ya gelatine muri farumasi ikomeje, uruhare rwayo rwageragejwe nkibintu biranga ibintu neza ntirugira inenge. Halal bovine gelatinikomoka mu nka kandi biremewe n'amategeko agenga imirire ya kisilamu, bityo irashobora gukoreshwa mubicuruzwa byinshi byemewe na halale

Gelatin igereranya ihuriro ntagereranywa ry’inkomoko karemano, ibinyabuzima, hamwe n’ikoranabuhanga rikoresha ikoranabuhanga, bigashimangira umwanya waryo mu bihe biri imbere by’imiti y’imiti mu myaka mirongo iri imbere.

Impamvu bifite akamaro munganda zimiti

Gelatin ni poroteyine isobanutse, idafite ibara, kandi ikurura amazi yakuwe muri hydrolysis igenzurwa na kolagen mu magufwa y’inyamaswa, uruhu, hamwe nuduce. Poroteyine karemano, igizwe ahanini ninshuro eshatu zumunyururu wa polypeptide zifatanije, ifite imitungo ituma ishobora gutera cyangwa kuguma mumazi. Ishingiye ku miterere yayo n'uburemere bwa molekile. Akenshi ikoreshwa nkibinyabuzima byinshi kandi byahinduwe nibinyabiziga bisohora ibiyobyabwenge (muri capsules-tableti) cyangwa kubisabwa mubuvuzi, gelatine ikoreshwa mumiti.

Gelatin: Uruhare rwayo mugutezimbere ibiyobyabwenge no gukoresha ubuvuzi

Umutungo wogukora neza urinda ibikoresho bya farumasi ibintu bidukikije mugihe biteza imbere ibiyobyabwenge no kwinjizwa. Bitewe na gelatin yagutse cyane, ni nayo nkingi yukuntu uburyo umusaruro ukenerwa wujujwe kugirango uhindurwe mubikorwa bya capsule.

Gelatin kandi ni biopolymer ifite umutekano, hypoallergenic hamwe na porogaramu nini nka spostes ya hemostatike mubuvuzi bushya no kubaga. Ndetse ikoreshwa nk'iyagura plasma y'amaraso, yemeza uruhare rwayo mu buvuzi bwa none.

Umwanzuro

Kubera imikorere yacyo, umutekano no kwemerwa kwisi yose, imiti ya gelatineikoreshwa kandi muri gelatin capsules. G.latinAbahinguzi bongera ubwitange kubuzima bw’abarwayi bibanda ku guhuza imiterere y’isuku no gushyigikira ikoranabuhanga ryo gutanga ibisubizo byatanze ibisubizo byerekana uruhare rukomeye rwa Gelatin mu buvuzi bw’isi.